发明名称 |
Substituted aryl-indole compounds and their kynurenine/kynuramine-like metabolites as therapeutic agents |
摘要 |
This invention is directed to substituted aryl compounds, which are linked to a substituted indole moiety by various linkers, and the kynurenine/kynuramine-like metabolites of these agents, their preparation and pharmaceutical compositions containing these compounds. This invention further is directed to the pharmaceutical use of the compounds for inhibiting GSK3² kinase and/or modulating N-methyl-D-aspartate (NMDA) channel activities for the treatment of neurodegenerative and other disorders. |
申请公布号 |
EP2664615(A1) |
申请公布日期 |
2013.11.20 |
申请号 |
EP20130179983 |
申请日期 |
2007.10.03 |
申请人 |
NEURIM PHARMACEUTICALS (1991) LIMITED |
发明人 |
PELEG-SCHULMAN, TAL;LAUDON, MOSHE;DAILY, DVORAH |
分类号 |
C07D209/16;A61K31/4045;A61P25/28;C07C225/22;C07C255/58;C07C317/36;C07D209/14 |
主分类号 |
C07D209/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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