The present invention provides novel pyrimidine amines of formula I which are potent inhibitors of spleen tyrosine kinase, and are useful in the treatment and prevention of diseases mediated by said enzyme, such as asthma, COPD, rheumatoid arthritis, and cancer.
申请公布号
AU2012253886(A1)
申请公布日期
2013.10.31
申请号
AU20120253886
申请日期
2012.05.04
申请人
MERCK SHARP & DOHME CORP.
发明人
ALTMAN, MICHAEL D.;DI FRANCESCO, MARIA EMILIA;HAIDLE, ANDREW M.;OTTE, RYAN D.;ELLIS, JOHN MICHAEL;CHILDERS, KALEEN KONRAD;NORTHRUP, ALAN B.;YANG, LIPING