发明名称 |
Fremgangsmåde til fremstilling af Telmisartan |
摘要 |
<p>Preparation of telmisartan (A) involves reacting 2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-benzimidazole (I) with a 4-(substituted methyl)-2'-cyanobiphenyl (IV), then hydrolyzing the cyano group of the obtained 2-cyano-4'-(2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-benzimidazol-1-ylmethyl)-biphenyl (V). Preparation of telmisartan (A) involves reacting 2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-benzimidazole(I) with a biphenyl derivative of formula (IV), then subjecting the 2-cyano-4'-(2-n-propyl-4-methyl-6-(1-methyl-benzimidazol-2-yl)-benzimidazol-1-ylmethyl)-biphenyl (V) (optionally after work-up) to hydrolysis of the cyano group to give the corresponding acid (A), which is optionally converted into the hydrochloride during work-up. [Image] Z' : leaving group, preferably halo (especially Br) or substituted sulfonyloxy. ACTIVITY : Hypotensive. MECHANISM OF ACTION : Angiotensin II receptor antagonist.</p> |
申请公布号 |
DK2322511(T3) |
申请公布日期 |
2013.10.28 |
申请号 |
DK20100192561T |
申请日期 |
2004.03.26 |
申请人 |
BOEHRINGER INGELHEIM INTERNATIONAL GMBH |
发明人 |
HAUEL, NORBERT;DACH, ROLF;HEITGER, HELMUT;MEYER, OLIVER |
分类号 |
C07D235/18;C07D235/04;C07D403/02;C07D403/04 |
主分类号 |
C07D235/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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