发明名称 |
Transferrin variants and conjugates |
摘要 |
<p>Based on the three-dimensional structure of transferrin, the inventors have designed variant polypeptides (muteins) which have one or more Cysteine residues with a free thiol group (hereinafter referred to as "thiotransferrin"). The variant polypeptide may be conjugated through the sulphur atom of the Cysteine residue to a bioactive compound.</p> |
申请公布号 |
EP2604623(A3) |
申请公布日期 |
2013.10.02 |
申请号 |
EP20120189421 |
申请日期 |
2008.08.08 |
申请人 |
NOVOZYMES BIOPHARMA DK A/S |
发明人 |
SLEEP, DARRELL;FRIIS, ESBEN PETER;HAY, JOANNA;FINNIS, CHRISTOPHER JOHN ARTHUR |
分类号 |
C07K14/79;A61K38/40;A61K47/48;C12N5/10 |
主分类号 |
C07K14/79 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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