发明名称 |
STABILIZED COMPOSITION OF A PROTON PUMP INHIBITOR |
摘要 |
It is intended to provide a pharmaceutical composition which contains a proton pump inhibitor and is stable even if it is stored for a long time. It is also intended to provide a pharmaceutical composition which contains a proton pump inhibitor susceptible to acid, and does not dissolve in the stomach but dissolves in the intestine to release a primary drug product promptly. The object could be achieved by the pharmaceutical composition characterized in that a layer containing a proton pump inhibitor and ethyl cellulose, a layer containing an enteric polymer, and if necessary an intermediate layer composed of one or more layers are formed on a pharmacologically inactive core substance. The intermediate layer is composed of a water-insoluble polymer, a water-soluble polymer, a lubricant and the like.
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申请公布号 |
CA2605839(C) |
申请公布日期 |
2013.10.01 |
申请号 |
CA20062605839 |
申请日期 |
2006.04.17 |
申请人 |
EISAI R & D MANAGEMENT CO., LTD. |
发明人 |
UKAI, KOJI;TAKAMI, NORISHIGE |
分类号 |
A61K31/4439;A61K9/16;A61K9/20;A61K9/48;A61K47/32;A61K47/38 |
主分类号 |
A61K31/4439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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