Novel insulin derivatives having an extremely delayed time-action profile
摘要
The invention relates to novel insulin analogs having a basal time-action profile, which are characterized by the addition and/or substitution of negatively and positively charged amino acid residues and by an amidation of the C-terminal carboxy group of the B chain and histidine in position 8 of the insulin A chain. The invention also relates to the production and use thereof.
申请公布号
AU2009203810(B2)
申请公布日期
2013.07.25
申请号
AU20090203810
申请日期
2009.01.06
申请人
SANOFI-AVENTIS DEUTSCHLAND GMBH
发明人
MULLER, GUNTER;SOMMERFELD, MARK;TSCHANK, GEORG;HABERMANN, PAUL;WERNER, ULRICH;KURRLE, ROLAND;TENNAGELS, NORBERT;SEIPKE, GERHARD