发明名称 |
A METHOD FOR IDENTIFICATION, PREDICTION AND PROGNOSIS OF CANCER AGGRESSIVENESS |
摘要 |
A survival model, for each of one or more pairs of genes, includes a function of a corresponding measure of the ratio of expression levels of the pairs of genes. For each pair of genes, there is a corresponding a cut-off value, such that patients are classified according to whether the corresponding measure is above or below the cut-off value. It is proposed (in an algorithm called “DDgR”) that the cut-off value should be selected so as to maximise the separation of the respective survival curves of the two groups of patients. It is further proposed that, for each of a number of genes or gene pairs, a selection is made from multiple survival models. The selection is according to whether a proportionality assumption is obeyed and/or according to a measure of data fit, such as the Baysian Information Criterion (BIC). Specific gene pairs identified by the methods are named. |
申请公布号 |
EP2406728(A4) |
申请公布日期 |
2013.07.10 |
申请号 |
EP20100751101 |
申请日期 |
2010.03.10 |
申请人 |
AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH |
发明人 |
KUZNETSOV, VLADIMIR, A.;MOTAKIS, EFTHIMIOS |
分类号 |
G01N33/574;G06F19/20;G06F19/24 |
主分类号 |
G01N33/574 |
代理机构 |
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代理人 |
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地址 |
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