发明名称 |
Co-Processing Method and Formulations for HIV Attachment Inhibitor Prodrug Compound and Excipients |
摘要 |
A process for the production of a formulation of HIV attachment inhibitor piperazine tris salt prodrug compound involves dissolving the prodrug compound in a solvent to form a solution; adding a first quantity of a first anti-solvent to the solution; then dispersing a first quantity of HPMC in the solution; adding a second quantity of the first anti-solvent to the solution; dispersing a second quantity of HPMC in the solution; then adding a second anti-solvent to the solution so as to crystallize the compound with the HPMC and thereby form the formulation, wherein the second anti-solvent is a combination of acetone and isopropyl acetate (IPAC). The formulation is then washed, and dried.
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申请公布号 |
US2013164345(A1) |
申请公布日期 |
2013.06.27 |
申请号 |
US201213716306 |
申请日期 |
2012.12.17 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
CHANG SHIH-YING;KIENTZLER DONALD;ERDEMIR DENIZ;KIANG SAN;ROSENBAUM TAMAR |
分类号 |
A61K31/675;A61K9/14 |
主分类号 |
A61K31/675 |
代理机构 |
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主权项 |
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地址 |
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