发明名称 |
IDENTIFICATION OF STABILIZERS OF MULTIMERIC PROTEINS |
摘要 |
Disclosed herein are compounds and compositions thereof which find use in increasing stability of TTR tetramers reducing its tendency to misfold and form aggregates. Also provided herein are methods for using these compounds and compositions for increasing stability of TTR and thereby decreasing aggregate formation by TTR. Also disclosed herein are methods to screen for candidate compounds that increase stability of TTR. Also disclosed herein are heterobifunctional compounds that include a TTR binding compound connected to a targeting moiety via a linker, for use in disrupting PPIs of a target protein. |
申请公布号 |
EP2566333(A1) |
申请公布日期 |
2013.03.13 |
申请号 |
EP20110778340 |
申请日期 |
2011.05.05 |
申请人 |
THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY |
发明人 |
GRAEF, ISABELLA A.;ALHAMADSHEH, MAMOUN |
分类号 |
A61K31/428;A61K31/4196;A61K31/433;C07D231/12;C07D487/04;G01N21/64 |
主分类号 |
A61K31/428 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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