发明名称 |
Pharmaceutical use of substituted amides |
摘要 |
The use of substituted amides for modulating the activity of 11&bgr;-hydroxysteroid dehydro-genase type 1 (11&bgr;HSD1) and the use of these compounds as pharmaceutical composi-tions, are described. Also a novel class of substituted amides, their use in therapy, phar-maceutical compositions comprising the compounds, as well as their use in the manufac-ture of medicaments are described. The present compounds are modulators and more specifically inhibitors of the activity of 11&bgr;HSD1 and may be useful in the treatment of a range of medical disorders where a decreased intracellular concentration of active gluco-corticoid is desirable.
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申请公布号 |
US8383683(B2) |
申请公布日期 |
2013.02.26 |
申请号 |
US20080597129 |
申请日期 |
2008.04.10 |
申请人 |
HIGH POINT PHARMACEUTICALS, LLC;EBDRUP SOREN;ANDERSEN HENRIK SUNE |
发明人 |
EBDRUP SOREN;ANDERSEN HENRIK SUNE |
分类号 |
A61K31/165;A61P3/10;C07C233/91 |
主分类号 |
A61K31/165 |
代理机构 |
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地址 |
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