发明名称 COMPOSITION FOR SUPPRESSING EXPRESSION OF TARGET GENE
摘要 <P>PROBLEM TO BE SOLVED: To provide a composition or the like for suppressing an expression of a target gene. <P>SOLUTION: The composition comprises an RNA-encapsulated liposome which comprises complex particles and a lipid membrane for coating the complex particles, the complex particle comprising, as constituent components, a lead particle and an RNA including a sequence of 15 to 30 contiguous bases of a target gene mRNA and a sequence complementary to the above sequence. The composition includes a liquid containing a polar organic solvent in which the constituent components of the lipid membrane can be dissolved, the liquid containing the polar organic solvent in such a concentration that the constituent components of the lipid membrane can be dispersed and the composite particles can be dispersed. <P>COPYRIGHT: (C)2013,JPO&INPIT
申请公布号 JP2013010786(A) 申请公布日期 2013.01.17
申请号 JP20120205586 申请日期 2012.09.19
申请人 KYOWA HAKKO KIRIN CO LTD 发明人 YAMAUCHI MASAHIRO;TOTTORI TSUNEAKI;ISHIHARA ATSUSHI;YAGI NOBUHIRO;KATO YASUKI
分类号 A61K31/713;A61K9/127;A61K47/34;A61P9/00;A61P29/00;A61P35/00;C12N15/113 主分类号 A61K31/713
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