| 摘要 |
The present application relates to methods of administering a nucleic acid-based therapeutic, to treat a disease or disorder in a patient. The methods suitably comprise administering a first dose amount of a nucleic acid-based therapeutic during a first treatment cycle, and administering a second dose amount of the nucleic acid-based therapeutic during subsequent treatment cycles, wherein the first dose amount is lower than the second dose amount. In embodiments, the nucleic acid-based therapeutic is an siRNA that is part of a composition comprising a cyclodextrin polymer. |
