摘要 |
The present application discloses a nanoparticle comprising compounds of the formula A-B- C(-D), wherein A designates an anchoring moiety having self-organizing properties in relation to the nanoparticle; B designates a cleavable linker; C designates an anionic moiety having a net charge of at least -2 at p H 6.0; and D, which is optional, designates a polymer moiety which induces long circulating properties of the nanoparticle in mammalian tissue; and wherein the average net charge of the compounds is at least -1 at p H 6.0. The application also discloses the individual compounds of the formula A-B-C(-D) as well as a drug delivery system comprising the self-organized nanoparticle having included in the interior thereof one or more pharmaceutically active agents and/or diagnostically relevant species, and a method of treating a cancerous or inflammatory condition in a mammal, involving the administration of the drug delivery system to the mammal. |
申请人 |
DANMARKS TEKNISKE UNIVERSITET;JOELCK, RASMUS IRMING;HENRIKSEN, JONAS, ROSAGER;GJETTING, TORBEN;ANDRESEN, THOMAS, LARS |
发明人 |
JOELCK, RASMUS IRMING;HENRIKSEN, JONAS, ROSAGER;GJETTING, TORBEN;ANDRESEN, THOMAS, LARS |