发明名称 |
METHOD FOR THE SELECTION OF A LONG-TERM PRODUCING CELL. |
摘要 |
Herein is reported a method for determining methylation of a promoter nucleic acid operably linked to a nucleic acid encoding a polypeptide and thereby determining the long-term productivity of a cell. Also an aspect is a method for selecting a cell for producing a polypeptide by determining the methylation of the promoter nucleic acid operably linked to the structural gene encoding the polypeptide. |
申请公布号 |
MX2012011738(A) |
申请公布日期 |
2012.11.16 |
申请号 |
MX20120011738 |
申请日期 |
2011.04.13 |
申请人 |
F. HOFFMANN-LA ROCHE AG.* |
发明人 |
ULRICH GOEPFERT;ANDREA OSTERLEHNER;SILKE SIMMETH |
分类号 |
C12Q1/68;C07K16/00;C12P21/02 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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