This invention relates to cytotoxic variants of human ribonuclease 1 (RNase 1) identified through analysis of the interaction between RNase 1 and the human ribonuclease inhibitor (hRI) as defined by the three dimensional (3-D) atomic structure of the RNase1 hRI complex. Also disclosed is the 3-D structure of the hRI•RNase 1 complex and methods for designing the RNase 1 variants.
申请公布号
US8293872(B2)
申请公布日期
2012.10.23
申请号
US201113243373
申请日期
2011.09.23
申请人
RAINES RONALD T.;PHILLIPS, JR. GEORGE N.;JOHNSON R. JEREMY;MCCOY JASON G.;WISCONSIN ALUMNI RESEARCH FOUNDATION
发明人
RAINES RONALD T.;PHILLIPS, JR. GEORGE N.;JOHNSON R. JEREMY;MCCOY JASON G.