METHOD OF PRODUCING HIGH-PURITY POLYETHYLENE GLYCOL-ALDEHYDE DERIVATIVES

摘要

FIELD: chemistry. ^ SUBSTANCE: invention relates to a method of producing high-purity polyethylene glycol-aldehyde compounds of general formula OHC-(CH2)k-1-O-(CH2CH2O)n-(CH2)k-1CHO. The method of producing said compounds is realised by reacting a polyethylene glycol derivative of formula: HO-(CH2)k-O-(CH2CH2O)n-(CH2)k-OH, with dimethylsulphoxide and dicyclohexylcarbodiimide. ^ EFFECT: method of producing polyethylene glycol-aldehyde compounds is cheap and said compounds can be used to improve solubility and efficiency of medicinal substances owing to binding thereto without impurities. ^ 11 cl, 3 ex