Method for the preparation of bacteriophages

摘要

The proposed method permits the single-stage and effective purification of phage preparations of therapeutic significance, makes it possible to retain the antibacterial activities of bacteriophages, both in the case of a strategy based on the displacement of bound bacteriophages from the gel as well as on proteolytic release. Modification of phage capsid proteins with appropriate binding motifs makes it possible to purify therapeutic strains of bacteriophages using affinity chromatography.