DENDRITIC CELLS (DCS) TARGETING FOR TUBERCULOSIS (TB) VACCINE
摘要
<p>Compositions and methods comprising high affinity monoclonal antibody conjugates against several DC receptors are described herein. The inventors prepared fusion proteins with antigens for DC-targeting vaccine generation by conjugating several M. tuberculosis protein antigens with high affinity monoclonal antibodies against several DC receptors with a view to developing novel human vaccines based on in vivo DC-targeting. The findings of studies described herein indicate that vaccines bearing TB antigens can recall a potent memory antigen-specific T cell response in vitro resulting in IFNy secretion.</p>
申请公布号
WO2012129227(A1)
申请公布日期
2012.09.27
申请号
WO2012US29802
申请日期
2012.03.20
申请人
BAYLOR RESEARCH INSTITUTE;LECINE, PATRICK;LEVY, YVES;ZURAWSKI, GERARD;BANCHEREAU, JACQUES F.
发明人
LECINE, PATRICK;LEVY, YVES;ZURAWSKI, GERARD;BANCHEREAU, JACQUES F.