发明名称 |
GENE DELIVERY COMPLEX COMPRISING RENAL CELL-SPECIFIC PEPTIDE AND POLYESTER AMINE AND COMPOSITION COMPRISING THE SAME FOR PREVENTING OR TREATING OF RENAL FIBROSIS |
摘要 |
PURPOSE: A gene delivery system containing renal cell-specific peptides and polyester amine polymers is provided to effectively deliver HGF gene to a target site and to suppress fibrosis. CONSTITUTION: A gene delivery system contains renal cell-specific peptides and polyester amine polymers. The renal cell-specific peptide is HOOC-ELRGDRAHW-NH_2. The polyester amine polymer is a copolymer of polyethylenimine and glycerol dimethacrylate. The delivery system is prepared by amide bond of a carboxyl group of rental cell-specific peptides and an amine group of polyester amine polymers. A HGF gene contains a base of sequence number 1. A composition for preventing or treating rental fibrosis contains a gene delivery complex.
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申请公布号 |
KR20120098022(A) |
申请公布日期 |
2012.09.05 |
申请号 |
KR20110017687 |
申请日期 |
2011.02.28 |
申请人 |
SNU R&DB FOUNDATION;EYUN PHARM CO., LTD. |
发明人 |
CHO, MYUNG HAING;CHO, CHONG SU;SEO, BO SEUNG;JUNG, HEYON SIK |
分类号 |
A61K47/48;A61K9/08;A61K9/14;A61P13/12 |
主分类号 |
A61K47/48 |
代理机构 |
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主权项 |
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