The present invention provides for the identification of an antigen surrogate to the native antigens for the autoimmune disease pemphigus vulgaris. Ligands are discovered using large random peptoid or cyclic peptoid libraries that are screened against known antibodies to autoimmune diseases. The ligands may be useful as drugs in the treatment of such diseases and can also be used in combination with the comcomitant removal of T-cells associated with autoimmune disorders.
申请公布号
WO2012096893(A2)
申请公布日期
2012.07.19
申请号
WO2012US20660
申请日期
2012.01.09
申请人
OPKO PHARMACEUTICALS, LLC;FROST, PHILLIP;KODADEK, THOMAS