| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention relates to medicine, particularly to ophthalmology. An ophthalmic device comprises a polymer matrix which in turn contains a biologically active agent and a carrier. The ophthalmic device is applicable for release of the biologically active agent induced by one or more amounts of lachrymal components from the polymer matrix in contact with tears in an eye. A method for making the ophthalmic device involves mixing a matrix-forming substance, the carrier and the biologically active agent, introducing a mixture into a cast for making the device and polymerising the matrix-forming substance in the cast. A method for biologically active agent delivery to a subject involves subject's eye contact with the device wherein one or more amounts of the lachrymal components release the biologically active agent from the device. ^ EFFECT: invention provides the stable ophthalmic device which is effective to deliver the biologically active agents into patient's eyes for long periods of time. ^ 19 cl, 4 dwg |
