发明名称 |
PHARMACEUTICAL COMPOSITIONS AND DOSAGE FORMS FOR ADMINISTRATION OF HYDROPHOBIC DRUGS |
摘要 |
Pharmaceutical compositions and dosage forms for administration of hydrophobic drugs, particularly steroids, are provided. The pharmaceutical compositions include a therapeutically effective amount of a hydrophobic drug, preferably a steroid; a solubilizer, preferably a vitamin E substance; and a surfactant. The synergistic effect between the hydrophobic drug and the vitamin E substance results in a pharmaceutical formulation with improved dispersion of both the active agent and the solubilizer. As a result of the improved dispersion, the pharmaceutical composition has improved bioavailability upon administration. Methods of improving the bioavailability of hydrophobic drugs administered to a patient are also provided. |
申请公布号 |
CA2526616(C) |
申请公布日期 |
2012.05.15 |
申请号 |
CA20042526616 |
申请日期 |
2004.05.24 |
申请人 |
LIPOCINE, INC. |
发明人 |
CHEN, FENG-JING;PATEL, MAHESH V.;FIKSTAD, DAVID T.;ZHANG, HUIPING;GILIYAR, CHANDRASHEKAR |
分类号 |
A61K31/57;A61B17/00;A61B17/04;A61K;A61K9/00;A61K9/107;A61K9/22;A61K9/26;A61K9/32;A61K9/48;A61K9/50;A61K9/52;A61K9/54;A61K9/56;A61K9/58;A61K9/64;A61K31/216;A61K31/56;A61K31/566;A61K31/568;A61K47/22;A61L |
主分类号 |
A61K31/57 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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