发明名称 |
DIAGNOSTIC BIOMARKERS FOR FIBROTIC DISORDERS |
摘要 |
The present invention provides novel methods of inhibiting fibrosis, as well as methods of treating or inhibiting fibrotic disorders, using BMP9 and/or BMP10 antagonists. The present invention also provides methods of assessing whether a subject has or is at risk of developing a fibrotic disorder by detecting levels of BMP9 and/or BMP10. Further provided are methods of assessing the efficacy of a treatment regimen for treating a fibrotic disorder by detecting and comparing pre-treatment levels of BMP9 and BMP10 with post-treatment levels of BMP9 and BMP10. |
申请公布号 |
EP2427494(A1) |
申请公布日期 |
2012.03.14 |
申请号 |
EP20100717658 |
申请日期 |
2010.05.07 |
申请人 |
NOVARTIS AG |
发明人 |
BUCKLER, ALAN;CHEN, CHAO-MIN;GUY, CHANTALE;HEWETT, JEFFREY |
分类号 |
C07K16/22;A61P43/00 |
主分类号 |
C07K16/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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