Methods for inhibiting the development of Huntington's disease

摘要

This invention relates to Huntington's disease and more specifically to methods for inhibiting the development of or treating Huntington's disease by administering estrogen, testosterone, precursors thereof or combinations thereof.

主权项

1. A method of determining if administration of 17β-estradiol or testosterone is needed in an individual having a Huntington's Disease (HD) gene with a number of CAG repeats between about 36 and about 120, the method comprising:
a. determining a level is below normal when the level is less than about 100 pg/ml for 17β-estradiol, less than about 20 pg/ml for free testosterone, or less than about 300 ng/dL for total testosterone; and b. administering an amount of 17β-estradiol or an amount of testosterone when the level is below normal; wherein determining the level of 17β-estradiol and the need to administer an amount of 17β-estradiol are for a female individual, and wherein determining the level of free testosterone or total testosterone and the need to administer an amount of testosterone are for a male individual.