发明名称 |
INDUCED PLURIPOTENT STEM CELLS |
摘要 |
Described herein is a major breakthrough in nuclear reprogramming and induced pluripotent stem cell (iPSC) technology. Fusion of the powerful transcription activation domain (TAD) of MyoD to the Oct4 protein makes iPSCs generation faster, more efficient, purer, safer and feeder-free. Also, disclosed herein is the first report of the use of a TAD fused to a transcription factor as a method for making iPSCs. By combining transcription factors and TADs, this approach to nuclear reprogramming can have a range of applications from inducing pluriopotency to inducing transdifferentiation without transitioning through iPSCs. |
申请公布号 |
WO2012012708(A1) |
申请公布日期 |
2012.01.26 |
申请号 |
WO2011US44995 |
申请日期 |
2011.07.22 |
申请人 |
REGENTS OF THE UNIVERSITY OF MINNESOTA;KIKYO, NOBUAKI;HIRAI, HIROYUKI |
发明人 |
KIKYO, NOBUAKI;HIRAI, HIROYUKI |
分类号 |
C12P21/04;C07H21/04;C12N5/00;C12N5/02 |
主分类号 |
C12P21/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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