7-aza-spiro[3.5]nonane-7-carboxylate derivatives, preparation thereof, and therapeutic use thereof

摘要

The invention relates to compounds of the general formula (I) where: R is a hydrogen or fluorine atom or a hydroxyl, cyano, trifluoromethyl, C-alkyl, C-alkoxy, or NRR group; m, n, o and p independently are a number from 0 to 3, provided that m+n≤7 and that o+p≤7; A is a covalent bond, an oxygen atom, a C-alkylene group or a -O-C-alkylene group in which the end that is an oxygen atom is bonded to the Rgroup and the end that is an alkylene group is bonded to the carbon of the bicyclic compound; R is an optionally substituted aryl or heteroaryl group; R is a hydrogen or fluorine atom or a C-alkyl or trifluoromethyl group; R is an optionally substituted 5-membered heterocyclic compounds; wherein the compounds can be in the state of a base or an acid addition salt. The invention can be used in therapeutics.