发明名称 |
LACTAM-CONTAINING COMPOUNDS AND DERIVATIVES THEREOF AS FACTOR XA INHIBITORS |
摘要 |
The present application describes lactam-containing compounds and derivatives thereof of Formula I: P4—P-M-M4  I or pharmaceutically acceptable salt forms thereof, wherein ring P, if present is a 5-7 membered carbocycle or heterocycle and ring M is a 5-7 membered carbocycle or heterocycle. Compounds of the present invention are useful as inhibitors of trypsin-like serine proteases, specifically factor Xa.
|
申请公布号 |
US2011212930(A1) |
申请公布日期 |
2011.09.01 |
申请号 |
US201113101536 |
申请日期 |
2011.05.05 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
PINTO DONALD J.P.;QUAN MIMI L.;ORWAT MICHAEL J.;LI YUN-LONG;HAN WEI;QIAO JENNIFER X.;LAM PATRICK Y.S.;KOCH STEPHANIE L. |
分类号 |
A61K31/616;C07D401/10;A61K31/4365;A61K31/437;A61K31/4439;A61K31/444;A61K31/4545;A61K31/496;A61K31/506;A61K31/513;A61K31/517;A61K31/55;A61K31/553;A61P7/02;A61P9/00;A61P9/10;C07D401/12;C07D401/14;C07D413/14;C07D471/04;C07D471/16 |
主分类号 |
A61K31/616 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|