| 摘要 |
The present invention describes a previously unknown interaction between secreted aspartic proteases (SAPs), including SAPs 4-6 of Candida albicans, and integrins on host cells. The SAPs secure entry into the host cell through RGD-like binding motifs and subsequently induce apoptosis, thereby clearing the way for systemic infection. The invention thus provide a new target for therapeutic intervention and describes peptides and antibodies that inhibit the action of SAPs in this context, including their interaction with integrins. |
