发明名称 |
Generation of transgenic human soluble amyloid precursor protein alpha expressing mice |
摘要 |
The present invention relates to a novel animal model for neurological degenerative diseases, especially autism, relating to overexpression of human secreted APP-alpha. This novel animal model exhibits several aspects of amyloidopathy. The present invention also relates to a method for producing the double transgenic animals, to cells and cell lines derived from these animals. Moreover, a method for the evaluation of the in vivo effects of a test compound on secreted APP-alpha expression and autism pathology in these animals is provided.
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申请公布号 |
US8008539(B1) |
申请公布日期 |
2011.08.30 |
申请号 |
US20100727679 |
申请日期 |
2010.03.19 |
申请人 |
UNIVERSITY OF SOUTH FLORIDA |
发明人 |
TAN JUN;NIKOLIC WILLIAM;HOU HUYAN |
分类号 |
A01K67/00;A01K67/033;G01N33/00 |
主分类号 |
A01K67/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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