发明名称 |
COMPOSITION OF DEXIBUPROFEN TRANSDERMAL HYDROGEL |
摘要 |
<p>Stable non-alcoholic transdermal hydrogel of dexibuprofen was prepared by using a simple manufacturing process, and the experimental trials showed that the pH modifying agent, antioxidant and water miscible solvent are the essential excipients to obtain stable non-alcoholic transdermal hydrogel of dexibuprofen. The dexibuprofen hydrogel prepared using carbopol as a gelling polymer produced an opaque gel, whereas hydrogel prepared using hyroxypropyl methylcellulose (HPMC) as a gelling polymer produced a transparent gel. There was no significant changes observed with respect to physical description, pH, assay and particularly to the related substance values when the hydrogels were subjected to the stability study at accelerated condition (40°C / 75% RH) for 3 months in laminated tubes.</p> |
申请公布号 |
CA2784827(A1) |
申请公布日期 |
2011.06.23 |
申请号 |
CA20102784827 |
申请日期 |
2010.12.09 |
申请人 |
SHASUN PHARMACEUTICALS LIMITED |
发明人 |
BERGMAN, JEFFREY STUART;DEVARAJAN, SAMPATHKUMAR;RAMALINGAM, SELVAKUMAR;PALANISAMY, ANANDSENTHIL VEL |
分类号 |
A61K9/06;A61K31/192;A61K47/36;A61K47/38 |
主分类号 |
A61K9/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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