发明名称 |
Chimeric Relaxin Polypeptides Comprising an A and B Chain Derived From Different Relaxin Family Peptides |
摘要 |
Provided herein are modified relaxin polypeptides wherein the B chain comprises the core amino acid sequence CGR-XXX-R-XX-I/V-XX-CG (SEQ ID NO:1), where X is any amino acid. Also provided are modified relaxin polypeptides comprising at least an A and a B chain, wherein the A and B chains are derived from different naturally occurring relaxins and wherein the B chain comprises the core amino acid sequence CGR-XXX-R-XX-I/V-XX-CG (SEQ ID NO:1), where X is any amino acid.
|
申请公布号 |
US2011092418(A1) |
申请公布日期 |
2011.04.21 |
申请号 |
US20080740450 |
申请日期 |
2008.10.30 |
申请人 |
FLOREKY INSTITUTE OF EXPERIMENTAL PHYSIOLOGY AND MEDICINE |
发明人 |
BATHGATE ROSS ALEXANDER DAVID;HOSSAIN MOHAMMED AKHTER;SAMUEL CHRISHAN SURENDRAN;WADE JOHN DESMOND;TREGEAR GEOFFREY W. |
分类号 |
C07K14/64;A61K38/02;A61K38/10;A61K38/30;C07K7/08;C07K14/475;C07K14/62 |
主分类号 |
C07K14/64 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|