发明名称 Morpholine dopamine agonists
摘要 The present invention provides for compounds of formula (I), (Ia) and (Ib) Wherein: A is selected from C—X and N, B is selected from C—Y and N, R1 is selected from H and (C1-C6)alkyl, R2 is selected from H and (C1-C6)alkyl, X is selected from H, HO, C(O)NH2, NH2 Y is selected from H, HO, NH2, Br, Cl and F Z is selected from H, HO, F, CONH2 and CN; And pharmaceutically acceptable salts, solvates and prodrugs thereof; With the provisos that: for a compound of formula (I), (Ia) or (Ib), when A is C—X, B is C—Y, R1 is H or (C1-C6)alkyl and R2 is H or (C1-C6)alkyl at least one of X, Y and Z must be OH; for a compound of formula (I), when A is C—X and B is C—Y, Y is H, Z is H, R1 is H and R2 is H, then X cannot be OH; these compounds are useful as a medicament.
申请公布号 US7902188(B2) 申请公布日期 2011.03.08
申请号 US20090496864 申请日期 2009.07.02
申请人 PFIZER INC. 发明人 ALLERTON CHARLOTTE MOIRA NORFOR;BAXTER ANDREW DOUGLAS;COOK ANDREW SIMON;HEPWORTH DAVID;WONG STEPHEN KWOK-FUNG
分类号 A61K31/5375;C07D265/30;C07D413/04 主分类号 A61K31/5375
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