发明名称 |
Process for the preparation of Telmisartan |
摘要 |
The present invention encompasses a method for the preparation of Telmisartan comprises, through Telmisartan dihydrochloride comprises i) Condensing 4-Methyl-2-n-propyl-1H-benzimidazole-6-carboxylic acid with N-Methyl-O-phenylenediamine dihydrochloride to yields 4-methyl-6 (1-methyl benzimidazol-2-yl)-2-n-propyl 1H-benzimidazole ii) Treating 4-methyl-6-(1-methylbenzimidazol-2-yl)-2-n-propyl-1H-benzimidazole with 4′-(bromomethyl)-2-biphenyl-2-carboxylate in presence of a base in an organic solvent and isolating the ester as acid addition salt iii) Converting ester acid addition salt to Telmisartan dihydrochloride and iv) Converting Telmisartan dihydrochloride to Telmisartan.
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申请公布号 |
US7884214(B2) |
申请公布日期 |
2011.02.08 |
申请号 |
US20060064150 |
申请日期 |
2006.07.19 |
申请人 |
MATRIX LABORATORIES LIMITED |
发明人 |
CHAVA SATYANARAYANA;GORANTLA SEETA RAMANJANEYULU;GINJUPALLI SAI PRASANNA BHAGYA LAKSHMI |
分类号 |
C07D403/02 |
主分类号 |
C07D403/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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