The present invention provides a chimaeric coronavirus S protein which is based on an S protein from a coronavirus strain with restricted tissue tropism, but which comprises at least part of the S2 subunit from a coronavirus strain with extended tissue tropism, such that a virus comprising the chimaeric S protein has extended tissue tropism. The present invention also provides a virus comprising such a chimaeric S protein.
申请公布号
WO2011004146(A1)
申请公布日期
2011.01.13
申请号
WO2010GB01293
申请日期
2010.07.05
申请人
INSTITUTE FOR ANIMAL HEALTH;BRITTON, PAUL;BICKERTON, ERICA;ARMESTO, MARIA