发明名称 IDENTIFICATION OF NOVEL BROADLY CROSS-REACTIVE NEUTRALIZING HUMAN MONOCLONAL ANTIBODIES USING SEQUENTIAL ANTIGEN PANNING OF PHAGE DISPLAY LIBRARIES
摘要 The present invention provides a method of identifying novel broadly crossreactive neutralizing monoclonal antibodies using sequential antigen panning of phage display libraries, antibodies obtained in accordance with such a method, as well as fusion proteins and conjugates comprising same, and related isolated or purified nucleic acid molecules, vectors, host cells, compositions, and methods of use to inhibit an infection, reduce the severity of an infection, treat an infection, and inhibit cancer.
申请公布号 US2010317837(A1) 申请公布日期 2010.12.16
申请号 US20100869198 申请日期 2010.08.26
申请人 THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEP. OF HEALTH AND HUMAN SERVICES 发明人 DIMITROV DIMITER S.;ZHANG MEI-YUN
分类号 C07K16/10;C07K16/00;C12N15/10 主分类号 C07K16/10
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