SOLUBLE MYOSTATIN PRO-DOMAIN RECOMBINANT PROTEIN HAVING MYOSTATIN INHIBITORY ACTIVITY AND USE THEREOF

摘要

The present invention relates to a soluble myostatin pro-domain recombinant protein having a myostatin inhibition activity. The recombinant protein having a myostatin prodomain, such as pMALc2x-prodomain and pET32a-prodomain, has an inhibitory effect on myostatin activity. Administration of the protein to higher animals and plants, marine animals including zooplankton, and oceanophytes including phytoplankton inhibits the function of myostatin, thereby producing doubl-muscle or low-fat higher organisms or marine organisms. Said soluble myostatin pro-domain recombinant proteins can be used in manufacturing animal feed additives for enhancing the muscle growth and rate of gain of animals and plants, and medicines for the prevention and treatment of muscle-related diseases such as muscular atrophy or muscular dystrophy.