发明名称 |
Method for overexpression of zwitterionic polysaccharides |
摘要 |
The present invention is directed to methods for producing and selecting new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; compositions directed to the new mutant strains of B. fragilis that constitutively express a particular capsular polysaccharide or only selected capsular polysaccharides; improved methods for purification of individual capsular polysaccharides; and compositions directed to new res02 and inv19 genes and their gene products. Significantly, the present invention provides methods and compositions for overexpressing and purifying immunomodulatory capsular polysaccharide A (PSA) in high yield.
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申请公布号 |
US7803602(B2) |
申请公布日期 |
2010.09.28 |
申请号 |
US20070894552 |
申请日期 |
2007.08.20 |
申请人 |
THE BRIGHAM AND WOMAN'S HOSPITAL, INC. |
发明人 |
COMSTOCK LAURIE E.;WEINACHT KATJA G.;COYNE MICHAEL J.;KASPER DENNIS L.;TZIANABOS ARTHUR O. |
分类号 |
C12N1/20;C12N15/09;A01N63/00;A61K31/7088;A61K38/00;A61K48/00;A61P1/00;A61P29/00;A61P37/02;C07K14/195;C07K14/32;C07K14/47;C07K16/18;C07K19/00;C12N1/15;C12N1/19;C12N1/21;C12N5/10;C12N15/74;C12N15/87;C12P19/04;C12P19/34;C12P21/06;C12Q1/04 |
主分类号 |
C12N1/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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