METHODS FOR COVALENTLY ATTACHING A POLYMER TO A METHIONINE RESIDUE IN PROTEINS AND PEPTIDES
摘要
Conjugates of polypeptides and a polymeric moiety such as PEG covalently attached to the sulfur atom of a methionine side chain are disclosed. Processes of preparing such conjugates, including intermediates and reagents utilized therefore are also disclosed. Further disclosed are therapeutic uses of these conjugates.
申请公布号
WO2010023670(A3)
申请公布日期
2010.09.02
申请号
WO2009IL00832
申请日期
2009.08.27
申请人
INSIGHT BIOPHARMACEUTICALS LTD.;VAN GELDER, JOEL M.;SERBAN, ANDREI;TCHILIBON, SUSANNA;MIRON, DAPHNA
发明人
VAN GELDER, JOEL M.;SERBAN, ANDREI;TCHILIBON, SUSANNA;MIRON, DAPHNA