CROSS-SPECIES CHIMERIC RNA MOLECULES

摘要

Methods to reduce the expression of at least one gene of an intracellular pathogen in a host cell are provided, wherein the method comprises introducing into a host cell a heterologous polynucleotide comprising or encoding a miRNA that fuses with at least one mRNA of the pathogen and reduces the translation of the mRNA. Pharmaceutical compositions comprising such polynucleotides, wherein the reduction in pathogenic gene expression leads to an inhibition of growth or differentiation of the pathogen or a reduction in the infection of a host cell with the pathogen are also provided, along with methods of treating pathogen-derived diseases in subjects by administering the pharmaceutical compositions.