HETERO-MULTIVALENT BINDING AGENTS FOR MEMBERS OF THE TGFß SUPERFAMILY

摘要

The invention provides hetero-multivalent ligand binging agents (traps) for members of the TGF-ß superfamily, as well as methods for making and using such constructs. In an embodiment of the invention there is provided a hetero-multivalent binding agent with affinity for a member of the TGF-ß superfamily, said agent comprising the general structure (I): (k-[{r-}n -(m-(linker4-d]h, where bd1, bd2, bd3 and bd4 are polypeptide binding domains having an affinity for different sites on the same member or for different members of the TGF-ß superfamily, wherein at least two of bd1, bd2, bd3, and bd4 are different from each other.