| 发明名称 |
N'-NITROXYALKYLNICOTINAMIDES FOR THE TREATMENT OF CARDIOVASCULAR DISEASES |
| 摘要 |
<p>The invention relates to the novel N'-nitroxyalkylnicotinamide derivatives represented by the general formula (I) wherein R1 is C1C4 alkyl; R2 is hydrogen, C1-C4 alkyl, CH2OH or CH2ONO2; R3 is ONO2, CH2ONO2 or OH; provided that when R3 is OH, R2 is CH2ONO2; and X- is an organic or inorganic anion; as well as pharmaceutical compositions thereof and their use as a medicament, in particular, in the treatment of diseases of the cardiovascular system.</p> |
| 申请公布号 |
WO2010000673(A1) |
申请公布日期 |
2010.01.07 |
| 申请号 |
WO2009EP58017 |
申请日期 |
2009.06.26 |
| 申请人 |
POLITECHNIKA LODZKA;UNIWERSYTET JAGIELLONSKI;GEBICKI, JERZY;MARCINEK, ANDRZEJ;CHLOPICKI, STEFAN;ADAMUS, JAN;URBANIAK, MALGORZATA |
发明人 |
GEBICKI, JERZY;MARCINEK, ANDRZEJ;CHLOPICKI, STEFAN;ADAMUS, JAN;URBANIAK, MALGORZATA |
| 分类号 |
C07D213/82;A61K31/455;A61P9/06;A61P9/10;A61P9/14 |
主分类号 |
C07D213/82 |
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