| 摘要 |
FIELD: medicine. ^ SUBSTANCE: invention relates to novel pharmaceutical composition in form of lyophilizate. Lyophilizate is obtained by lyophilic drying of emulsion of "oil in water" type based of lecithin. Emulsion contains badly soluble in water or in oil active substance, effective quantity of antioxidant, emulsion stabiliser, dimethylsulphoxide, copolymer of lactide and glycolide and additive, which prevents enlargement of emulsion particles during freezing. Lyophilizate is characterised by high stability when dissolved by infusion liquids. ^ EFFECT: reconstructing of emulsion is realised during not more than 15 minutes and without application of additional equipment, restored emulsion containing not less than 80% of particles with size less than 200 nm. ^ 19 cl, 3 dwg, 3 tbl, 8 ex |
