IMPROVED CYTOKINE DESIGN

摘要

The present invention relates to novel cytokines, which have a modified selectivity/specificity for their cognate receptors. In particular, the invention relates to a variant TRAIL protein, which has superior selectivity for the death receptor 4 (TRAIL-RI ) over the death receptor 5 (TRAIL-R2). In addition, the invention relates to a variant TRAIL protein which exhibits superior selectivity for the death receptor 4 (TRAIL-R1 ) over the decoy receptors DcR1 (TRAIL- R3) and DcR2 (TRAIL-R4).