发明名称 |
Methods for identifying compounds that modulate vigilance states |
摘要 |
The invention provides a method of identifying a compound that alters vigilance. The method consists of contacting an invertebrate with a candidate compound, evaluating a vigilance property in the contacted invertebrate, and determining if the candidate compound alters the vigilance property in the contacted invertebrate. A candidate compound that alters the vigilance property in the contacted invertebrate is identified as a compound that alters vigilance. The invention also provides a method of identifying a vigilance enhancing compound that modulates homeostatic regulation or a vigilance diminishing compound that modulates homeostatic regulation. The method consists of contacting an invertebrate with a compound that increases or decreases vigilance, and determining the effect of the compound on a homeostatic regulatory property of vigilance. A compound that alters the homeostatic regulatory property is characterized as being a vigilance enhancing compound or a vigilance diminishing compound that modulates homeostatic regulation.
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申请公布号 |
US7468178(B2) |
申请公布日期 |
2008.12.23 |
申请号 |
US20040830909 |
申请日期 |
2004.04.22 |
申请人 |
NEUROSCIENCES RESEARCH FOUNDATION, INC. |
发明人 |
TONONI GIULIO;CIRELLI CHIARA;SHAW PAUL J.;GREENSPAN RALPH J. |
分类号 |
A61K49/00 |
主分类号 |
A61K49/00 |
代理机构 |
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地址 |
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