发明名称 |
TNFalpha-neutralizing antibodies |
摘要 |
The invention provides monoclonal antibodies that neutralize TNFalpha activity. The monoclonal antibodies may be rabbit monoclonal antibodies or monoclonal antibodies having CDR regions derived from those rabbit monoclonal antibodies. In certain embodiments, the monoclonal antibodies may be humanized. Methods of using the subject antibodies to inhibit TNFalpha activity, methods of treatment using those antibodies and kits containing the same are also provided. The invention finds use in a variety of research and medical applications.
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申请公布号 |
US7431927(B2) |
申请公布日期 |
2008.10.07 |
申请号 |
US20050090105 |
申请日期 |
2005.03.24 |
申请人 |
EPITOMICS, INC. |
发明人 |
COUTO FERNANDO JOSE REBELO DO;HENDRICKS KRISTIN BETH;WALLACE STACEY ELLEN |
分类号 |
A61K39/395;C07K16/24;C12N1/00;C12N1/16;C12N15/00;C12P21/08 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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