发明名称 |
ALPHA AMINOACID ESTER-DRUG CONJUGATES HYDROLYSABLE BY CARBOXYLESTERASE |
摘要 |
Covalent conjugation of an alpha amino acid ester to a modulator of the activity of a target intr acellular enzyme or receptor, wherein the ester group of the conjugate is hydrolysable by intracellular carboxylesterase enzyme hCE1 and not by hCE2 or hCE3 to the corresponding acid, leads to selective accumulation of the carboxylic acid hydrolysis product in monocyte/macrophage cell and enables improved or more prolonged enzyme or receptor modulation in those cells relative to the unconjugated modulator. |
申请公布号 |
EP1964578(A2) |
申请公布日期 |
2008.09.03 |
申请号 |
EP20080075301 |
申请日期 |
2006.05.04 |
申请人 |
CHROMA THERAPEUTICS LIMITED |
发明人 |
DAVIDSON, ALAN HORNSBY;DRUMMOND, ALAN HASTINGS;NEEDHAM, LINDSEY ANN |
分类号 |
A61K47/48 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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