| 摘要 |
A system for infusing a drug (10) under continuous positive pressure (such as convection enhanced deliver) to a target tissue (12) to be treated is particularly useful for post- resection anticancer drug therapy. The system comprises a drug infusion catheter (16) having an expandable device (28) which is expanded within the target tissue such that the target tissue conforms to an outer surface of the expandable device, thereby creating a form of seal around the target volume in order to maintain an effective drug pressure gradient within the target tissue. The system further comprises a sensor (50,52,54,56) to measure a parameter which can be correlated to the degree of conformance between the target tissue and the outer surface of the expandable device. The sensor is coupled to a feedback control system (22) to determine whether there is a loss of conformance, and to adjust the expansion of the expandable device in order to maintain good conformance. |
