摘要 |
The present invention is directed to processes for the synthesis of morphinans. In particular, a process for the asymmetric reduction of an imine moiety in a 3,4-dihydroisoquinoline to produce a tetrahydroisoquinoline, followed by a Birch reduction to produce a hexahydroisoquinoline. In various embodiments, the 3,4-dihydroisoquinoline contains a phenol moiety protected with a labile protecting group. In other embodiments, the imine reduction reaction mixture contains silver tetrafluoroborate. |
申请人 |
MALLINCKRODT INC.;WANG, PETER, X.;CANTRELL, GARY, L.;MAGPARANGALAN, DAN, P.;MOSER, FRANK, W.;BAO, JIAN;GROTE, CHRISTOPHER, W. |
发明人 |
WANG, PETER, X.;CANTRELL, GARY, L.;MAGPARANGALAN, DAN, P.;MOSER, FRANK, W.;BAO, JIAN;GROTE, CHRISTOPHER, W. |