Modulators of cell adhesion molecules and use thereof

摘要

The present invention is related to new molecules capable of decreasing or altering neuronal cell adhesion and especially cell aggregation induced by Necl/SynCAM molecules. In particular, the invention provides proteins useful in the treatment of neuro-inflammatory and neurodegenerative conditions. More particularly, the present invention provides novel proteins and antibodies, DNA encoding thereof, processes for production thereof, pharmaceutical compositions, kits containing thereof and the use of these in the preparation of pharmaceutical compositions for the treatment of neuroinflammatory and neurodegenerative conditions.