3-[4-(6-Pyridin-3-Yl)-3-Phenyl] -5-(1H-1,2,3-Triazol-1-Ylmethyl)-1,3-Oxazolidin-2-Ones as Antibacterial Agents

摘要

Compounds of the formula (I): or a pharmaceutically-acceptable salt or pro-drug thereof: wherein R¹ is selected for example from hydrogen, halogen, optionally substituted methyl; R² and R³ are independently selected from hydrogen, fluoro, chloro and trifluoromethyl; R⁴ and R⁵ are independently selected, for example, from hydrogen, methyl, optionally substituted (2-4C)alkyl, C(O)R⁶ or R⁴ and R⁵ together with the nitrogen to which they are attached form an optionally substituted 5 or 6 membered, saturated or partially unsaturated heterocyclyl ring or an optionally substituted imidazole ring. Methods for making the compounds of formula (I), compositions containing them and their use as antibacterial agents are also described.